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DOCTOR PROFESSOR OF DEPARTAMENT OF PHYSIOLOGY IN THE RIBEIRÃO PRETO MEDICAL SCHOOL/USP.
EDUCATION AND TRAINING
• 1993 Medicine, Federal University of Pará;
• 1998 Master in Physiology, University of São Paulo;
• 2002 Ph.D in Physiology, University of São Paulo;
• 2015 Post Doctoral training, The Salk Institute, La Jolla, CA, USA.
RESEARCH AREA
The main goal of our laboratory, founded by Dr. Renato H. Migliorini in 1954 in the Department of Physiology, is to investigate how hormones, nutrients and neural factors control the energetic metabolism in different species. Since 1995, Dr. Navegantes and Dr. Isis Kethellut work as a team to understand the regulation of protein, carbohydrate and lipid metabolism under physiological conditions and in the setting of metabolic dysfunctions.
New technologies associated with traditional biochemical methods are allowing us to explore the skeletal muscle, the liver and the white and brown adipose tissue and better undestand the molecular mechanisms and signaling pathways underlying:
1. The gain and loss of skeletal muscle mass.
2. The neuroendocrine control of hepatic glucose production.
3. The brown adipose tissue themogenesis .
4. The generation of glycerol-3-phosphate in white adipose tissue.
MAIN PUBLICATIONS
• Gonçalves DA, Lira EC, Baviera AM, Cao P, Zanon NM, Arany Z, Bedard N, Tanksale P, Wing SS, Lecker SH, Kettelhut IC, Navegantes LC. Mechanisms involved in 3′,5′-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle. Endocrinology. 2009 Dec;150(12):5395-404.
• Graça FA, Gonçalves DA, Silveira WA, Lira EC, Chaves VE, Zanon NM, Garófalo MA, Kettelhut IC, Navegantes LC. Epinephrine depletion exacerbates the fasting-induced protein breakdown in fast-twitch skeletal muscles. American Journal of Physiology: Endocrinology and Metabolism, v. 305, p. E1483-E1494, 2013.
• Cassolla P, Uchoa ET, Mansur Machado FS, Guimarães JB, Garófalo MAR, Brito NA, Elias LLK, Coimbra CC, Kettelhut IC, Navegantes, LC. The central administration of C75, a fatty acid synthase inhibitor, activates sympathetic outflow and thermogenesis in interscapular brown adipose tissue. Pfluegers Archiv, v. 465, p. 1687-1699, 2013.
• Machado J, Manfredi LH, Silveira WA, Gonçalves DA, Lustrino D, Zanon NM, Kettelhut IC, Navegantes LC. Calcitonin gene-related peptide inhibits autophagic-lysosomal proteolysis through cAMP/PKA signaling in rat skeletal muscles. Int. J. Biochem. Cell Biol., doi: 10.1016/j.biocel.2015.12.011, 2015.
• Khan MM, Lustrino D, Silveira WA, Wild F, Straka T, Issop Y, O’Connor E, Cox D, Reischl M, Marquardt T, Labeit D, Labeit S, Benoit E, Molgó J, Lochmüller H, Witzemann V, Kettelhut IC, Navegantes LC, Pozzan T, Rudolf R. Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease. Proc. Natl. Acad. Sci. USA. 2016 Jan 5. pii: 201524272. [Epub ahead of print]
GROUP
• Technicians: Neusa Maria Zanon, Maria Antonieta Garófalo e Lilian do Carmo
• Pos-Doc students: Dawit Albieiro Pinheiro Gonçalves, Wilian de Assis Silveira and Juliano Machado
• PhD. students: Natalia Lautherbach Ennes da Silva
• Graduated students: Heitor Bernardes
• Undergraduated students: Vínícius Taboni Lisboa
NETWORKS