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ASSISTANT PROFESSOR OF DEPARTAMENT OF PHYSIOLOGY IN THE RIBEIRÃO PRETO MEDICAL SCHOOL/USP.
Education and Training:
Ph.D: Physiology, School of Medicine of Ribeirão Preto, University of São Paulo – 2011.
Post-Doctoral positions:
i) Department of Physiology, School of Medicine of Ribeirão Preto/University of São Paulo.
ii) School of Physiology & Pharmacology – University of Bristol/UK.
Young Investigator position: Department of Physiology, School of Medicine of Ribeirão Preto/University of São Paulo.
Academic appointment:
2014-2017: Visiting Researcher at School of Physiology & Pharmacology – University of Bristol/UK.
Prizes:
i) The American Physiological Society Neural Control & Autonomic Regulation Section Michael J. Brody Young Investigator Award.
ii) The American Physiological Society Neural Control and Autonomic Regulation Postdoctoral and Early Career Research Recognition Award.
iii) The Neural Control and Autonomic Regulation Section New Investigator Award – American Physiological Society.
Research interest:
The research in my laboratory is aimed at understanding the mechanisms, at the level of the brainstem and spinal cord, underlying the generation and sensorial control of mammalian breathing. One of the fundamental challenges of contemporary Neuroscience is to explain the generation of motor behaviour in terms of the cellular and neural network properties of neural systems. Neural networks generating movement, particularly those that produce innate rhythmic motor behaviours, such as breathing and locomotion, provide important neural systems models to solve this problem. The Central Pattern Generator of breathing is one of the few neural systems that can generate behaviorally relevant patterns of neuronal activity in highly reduced mammalian central nervous system preparations. Using patch clamp, molecular biology, optogenetic and chemogenetic approaches in in vitro, in situ and in vivo preparations, my research seeks to understand the central generation and sensory control of respiratory movements at the molecular, biophysical, synaptic and neural network levels.
Selected publications:
1 – Moraes DJ, Bonagamba LGH, da Silva MP, Paton JFR, Machado BH. Role of ventral medullary catecholaminergic neurons for respiratory modulation of sympathetic outflow in rats. Sci Rep. 2017 Dec 4; 7 (1): 16883.
2 – de Britto AA, Moraes DJ. Non-chemosensitive parafacial neurons simultaneously regulate active expiration and airway patency under hypercapnia in rats. J Physiol. 2017 Mar 15; 595 (6): 2043-2064.
3 – Pijacka W, Moraes DJ, Ratcliffe LE, Nightingale AK, Hart EC, da Silva MP, Machado BH, McBryde FD, Abdala AP, Ford AP, Paton JF. Purinergic receptors in the carotid body as a new drug target for controlling hypertension. Nat Med. 2016 Oct; 22 (10): 1151-1159.
4 – Moraes DJ, Bonagamba LG, da Silva MP, Mecawi AS, Antunes-Rodrigues J, Machado BH. Respiratory Network Enhances the Sympathoinhibitory Component of Baroreflex of Rats Submitted to Chronic Intermittent Hypoxia. Hypertension. 2016 Oct; 68 (4): 1021-30.
5 – Moraes DJ, Machado BH, Paton JF. Carotid body overactivity induces respiratory neurone channelopathy contributing to neurogenic hypertension. J Physiol. 2015 Jul 15; 593 (14): 3055-63.
6 – Moraes DJ, Machado BH. Electrophysiological properties of laryngeal motoneurones in rats submitted to chronic intermittent hypoxia. J Physiol. 2015 Feb 1; 593 (3): 619-34.
7 – Moraes DJ, Machado BH, Paton JF. Specific respiratory neuron types have increased excitability that drive presympathetic neurones in neurogenic hypertension. Hypertension. 2014 Jun; 63 (6): 1309-18.
8 – Moraes DJ, Bonagamba LG, Costa KM, Costa-Silva JH, Zoccal DB, Machado BH. Short-term sustained hypoxia induces changes in the coupling of sympathetic and respiratory activities in rats. J Physiol. 2014 May 1; 592 (9): 2013-33.
9 – Moraes DJ, da Silva MP, Bonagamba LG, Mecawi AS, Zoccal DB, Antunes-Rodrigues J, Varanda WA, Machado BH. Electrophysiological properties of rostral ventrolateral medulla presympathetic neurons modulated by the respiratory network in rats. J Neurosci. 2013 Dec 4; 33 (49): 19223-37.
10 – McBryde FD, Abdala AP, Hendy EB, Pijacka W, Marvar P, Moraes DJ, Sobotka PA, Paton JF. The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. Nat Commun. 2013; 4: 2395.
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